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April 1982

Transient Thyroid Suppression Associated With Topically Applied Povidone-Iodine

Author Affiliations

Children's Hospital of Philadelphia Philadelphia

Am J Dis Child. 1982;136(4):369-370. doi:10.1001/archpedi.1982.03970400087025

The value of neonatal thyroid-screening programs is in the early detection of hypothyroidism due to a variety of causes.1 However, thyroid suppression associated with topical iodine applications has not been reported in any review of thyroid screening, to the best of our knowledge.

Report of a Case.—An infant boy was born at term, weighing 2.9 kg, to nonconsanguineous parents. The mother had had a normal pregnancy and had not taken any medications. There was no family history of thyroid disease. The baby fed poorly, and on the second day passed several brownish, blood-stained stools. He had a tender, distended, edematous abdomen. Abdominal roentgenogram showed air in the intestinal wall, and necrotizing enterocolitis was diagnosed. On the third day, during laparotomy, the descending colon was perforated and an ileostomy was performed.

At 8 days of age, the abdominal wound broke down; at 10 days, povidone-iodine (Betadine) was applied topically