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May 1982

Paraldehyde Toxicity During Treatment of Status Epilepticus

Author Affiliations

From the Children's Hospital Medical Center, Cincinnati. Dr Bostrom is now with the Department of Pediatrics, University of Minnesota Hospitals, Minneapolis.

Am J Dis Child. 1982;136(5):414-415. doi:10.1001/archpedi.1982.03970410032006

• A 2-month-old girl survived a lethal serum level of paraldehyde after being given the drug intravenously (IV) for status epilepticus. On the basis of known pharmacokinetic data in man, a slow IV infusion, over a period of five minutes, of 200 mg/kg of paraldehyde followed by a drip of 20 mg/kg/hr should result in safe, rapid control of status epilepticus when first-line anticonvulsant drugs have failed. The paraldehyde should be diluted to a 10% solution with 5% dextrose water.

(Am J Dis Child 1982;136:414-415)