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June 1982

Influenza Immunization in Children and Young Adults: Clinical Reactions and Total and IgM Antibody Responses After Immunization With Whole-Virus or Split-Product Influenza Vaccines

Author Affiliations

From the Department of Pediatrics, Division of Infectious Diseases, Center for the Health Sciences, UCLA School of Medicine, Los Angeles.

Am J Dis Child. 1982;136(6):513-517. doi:10.1001/archpedi.1982.03970420037007

• Clinical reactions and hemagglutinating-inhibiting (HAI) antibody responses to recent whole-virus and split-product influenza vaccines were studied in 168 children and young adults. The subjects initially received a monovalent vaccine, followed one month later by a trivalent preparation. The reactogenicity of whole-virus and split-product vaccines with an equivalent hemagglutinin content was similar except in the youngest age (6 to 36 months) group in which the whole-virus preparation was more reactogenic. The whole-virus vaccines were more immunogenic, especially in subjects who were previously unprimed (preimmunization HAI antibody titer, < 5). In these subjects, the geometric mean titers of HAI antibody were significantly higher after vaccination with whole-virus vaccines than with split-product vaccines. Specific IgM antibody was found more frequently after vaccination with whole-virus vaccines (34%) than after split-product vaccines (11%).

(Am J Dis Child 1982;136:513-517)