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July 1982

Calcium and Phosphate Supplements in Breast Milk–Related Rickets: Results in a Very-Low-Birth-Weight Infant

Author Affiliations

From the Newborn Division, Departments of Pediatrics (Drs Greer, Steichen, and Tsang) and Obstetrics and Gynecology (Dr Tsang), University of Cincinnati College of Medicine and Children's Hospital Medical Center, Cincinnati. Dr Greer is now with the Department of Pediatrics, University of Wisconsin, Madison.

Am J Dis Child. 1982;136(7):581-583. doi:10.1001/archpedi.1982.03970430013003

• Rickets developed in a very-low-birth-weight infant fed exclusively human milk. Serum 25-hydroxyvitamin D concentration was normal, and serum 1,25-dihydroxyvitamin D level was elevated; parathyroid hormone and calcitonin levels were normal. Rickets responded to supplements of calcium and phosphate, as determined by roentgenograms and measurement of bone mineral content by direct photon absorptiometry. Human-milk feeding in very-low-birth-weight infants requires observation for hypophosphatemia and clinical and radiological signs of rickets. In such infants, it may be necessary to supplement breast-milk feeding with calcium and phosphate.

(Am J Dis Child 1982;136:581-583)