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July 1982

Disseminated Aspergillosis

Author Affiliations

Istituto di Malattie Infettive University of Milan Via G. B. Grassi, 74 20157 Milan, Italy
Istituto di Clinica Medica II
Istituto di Igiene University of Milan Via F. Sforza, 35 20122 Milan, Italy

Am J Dis Child. 1982;136(7):654. doi:10.1001/archpedi.1982.03970430086035

Sir.—It is well known that disseminated aspergillosis in immunocompromised patients is a fatal disease. In children affected by chronic granulomatous disease (CGD), therapy with amphotericin B alone is only marginally effective, and granulocyte transfusions or a surgical approach are often required.

Corrado et al1 suggested the combined use of rifampin and amphotericin B to treat a child with CGD and aspergillosis.

We report a new case of systemic infection caused by Aspergillus fumigatus in a boy suffering from CGD in whom successful treatment has been obtained with the combination of amphotericin B and rifampin.

Report of a Case.—A 14-year-old boy who had CGD2 was admitted to the Division of Infectious Diseases, University of Milan, Italy, because he was febrile (39.5 °C) and had right-sided pneumonia with pleural effusion and two fluctuant masses over the lateral aspect of the chest wall on the right side. The diagnosis