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August 1982

Role of Neutrophil Antigen NA1 in an Infant With Autoimmune Neutropenia

Author Affiliations

From the Departments of Laboratory Medicine (Drs P. R. Madyastha, Genco, and Glassman), Pediatrics (Drs Kyong and Darby), and Basic and Clinical Immunology and Microbiology (Drs K. R. Madyastha and Fudenberg), Medical University of South Carolina, Charleston.

Am J Dis Child. 1982;136(8):718-721. doi:10.1001/archpedi.1982.03970440062018

• A nontransfused 14-month-old female infant was investigated for persistent neutropenia of eight months' duration, with absolute neutrophil counts ranging from 410 to 935 cu mm. The patient's sera reacted with neutrophils from her own peripheral blood, from normal donors, and from her mother, all these having the neutrophil antigen NA1, but not with neutrophils from NA1-negative donors, including the father. The autoantibody was detectable by capillary agglutination and by indirect immunofluorescence techniques but not by complement-dependent cytotoxicity. No antibody was found in the mother's serum. Studies on three occasions showed good correlation between the appearance of circulating autoantibody and the peripheral neutrophil counts. Our observations, together with previously published reports, suggest a possible relationship of NA1 antigen and the disease susceptibility or NA1-positive infants to autoimmune neutropenia.

(Am J Dis Child 1982;136:718-721)