[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
November 1982

Drug Treatment of Otitis Media and Urinary Tract Infections-Reply

Author Affiliations

Division of Infectious Diseases Children's Hospital of Michigan 3901 Beaubien Blvd Detroit, MI 48201

Am J Dis Child. 1982;136(11):1029. doi:10.1001/archpedi.1982.03970470073022

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


In Reply.—The P values stated in our article (Table 2) were based on one-tailed tests. As one of the cell sizes was zero in the thrombocytopenia comparison groups, we agree that Fisher's exact test would have been more appropriate. Obviously, more numbers are needed to arrive at meaningful statistical data. Neutropenia remains significantly more common in the group receiving sulfamethoxazole-trimethoprim, regardless of the method of analysis.

In our study, no attempt was made to elucidate the mechanism of neutropenia. The speculations of Drs Guess and Cohen may well indicate the operative mechanisms.

We agree that additional research on the incidence, severity, and mechanisms of hematologic reactions secondary to administration of sulfamethoxazole-trimethoprim is needed. Until more data are collected, however, we will continue to believe that it is prudent to monitor for potential abnormalities.

First Page Preview View Large
First page PDF preview
First page PDF preview