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January 1983

Factors Affecting Outcome in Hypoxic-Ischemic Encephalopathy in Term Infants

Author Affiliations

From the Northern and Central Alberta Perinatal Program (Drs Finer and Robertson), the Department of Neonatology, Royal Alexandra Hospital (Dr Finer, Ms Peters, and Mr Coward), the Neonatal Follow-up Clinic, Glenrose School Hospital (Dr Robertson), and the Department of Pediatrics, University of Alberta Medical School (Drs Finer and Robertson), Edmonton, Alberta.

Am J Dis Child. 1983;137(1):21-25. doi:10.1001/archpedi.1983.02140270017006

• Forty-nine term infants were prospectively shown to have hypoxic-ischemic encephalopathy (HIE). All infants survived the neonatal period, and all but two infants (seen at 12 months) were followed up to at least 27 months of age. Factors that significantly correlated with outcome included the Sarnat encephalopathy stage and the occurrence of intractable seizures not controlled by phenobarbital sodium alone. There was no association between the one- or five-minute Apgar score, the need for early ventilation, the EEG, the occurrence of seizures, and the subsequent outcome. There was no significant difference in outcome for those infants who received dexamethasone sodium phosphate (n=29) v those who did not receive the drug (n=20). A review of 97 term infants with HIE from a regional perinatal program during a one-year period (1979), including 35 of the 49 infants in the present study, did show a significant increase in morbidity and mortality for transported infants.

(Am J Dis Child 1983;137:21-25)