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February 1983

Acromegaly and Hyperprolactinemia in McCune-Albright Syndrome: Evidence of Hypothalamic Dysfunction

Author Affiliations

From the Departments of Medicine (Dr Chung and Prof Guz) and Chemical Pathology (Dr Alaghband-Zadeh), Charing Cross Hospital Medical School, London.

Am J Dis Child. 1983;137(2):134-136. doi:10.1001/archpedi.1983.02140280032008

• In a 21-year-old woman with McCune-Albright syndrome, acromegaly and hyperprolactinemia with hypopituitarism developed secondary to a large pituitary tumor. Bromocriptine suppressed the secretion of growth hormone and prolactin, with a reduction in tumor size. However, at the age of 8, she already showed evidence of biochemical acromegaly, with a paradoxical rise of growth hormone levels during two glucose tolerance tests, in the presence of a radiologically normal pituitary fossa. These data support the hypothesis that long-standing hypothalamic stimulation may have been responsible for the later development of a pituitary tumor.

(Am J Dis Child 1983;137:134-136)