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This book is volume 7 of a series that is better known to pathologists than pediatricians. Each volume contains a collection of approximately ten state-of-the-art or review chapters on diverse subjects, each written by a pediatric pathologist acknowledged to be expert in his or her field. This particular volume would be of special interest to many subspecialist pediatricians because most of the contributions concern clinically relevant topics.
Geneticists and perinatologists would particularly appreciate the first four chapters, all of which deal with developmental abnormalities. The opening chapter "Developmental and Other Pathologic Changes in Syndromes Caused by Chromosomal Abnormalities" by Enid Gilbert and John Opitz is written in two sections. The first section deals with general biologic effects of chromosomal disorders and mechanisms of maldevelopment associated with them. The second section is a magnificent and well-illustrated encyclopedic review of the clinical and pathologic manifestations of trisomies 21, 13, 18, 22, 8,