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April 1983

A Model for Studying the Pathogenesis and Incidence of Low-Birth-Weight Infants

Author Affiliations

From the Department of Pediatrics, University of Kansas Medical Center, College of Health Sciences and Hospital, Kansas City. Dr Miller is now retired and lives in Northford, Conn.

Am J Dis Child. 1983;137(4):323-327. doi:10.1001/archpedi.1983.02140300005002

• A model is proposed for analyzing the many extrinsic and intrinsic factors that might affect the incidence of low-birth-weight (LBW) infants (<2,501 g) adversely in populations of variable socioeconomic status (SES). The model provides for categorizing all mothers either into one of four broad categories of extrinsic factors or into a normal group, free of all extrinsic factors. Application of the model in a prospective study of 972 infants showed that the incidence of LBW infants was low in normal pregnancies and significantly higher in the categories of extrinsic factors, that SES had a limited role in the birth of LBW infants, and that intrinsic factors had an almost negligible adverse effect if properly controlled.

(Am J Dis Child 1983;137:323-327)