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April 1983

Effect of Antenatal Glucocorticoids on Clinical Closure of the Ductus Arteriosus

Author Affiliations

From the Departments of Pediatrics (Drs Waffarn, Siassi, and Cabal) and Obstetrics and Gynecology (Dr Schmidt), University of Southern California School of Medicine and Los Angeles County—University of Southern California Medical Center, Los Angeles. Dr Waffarn is now with the University of California Irvine Medical Center, Orange.

Am J Dis Child. 1983;137(4):336-338. doi:10.1001/archpedi.1983.02140300018005

• The incidence of clinically detectable patent ductus arteriosus (PDA) in a group of preterm infants whose birth weights were less than 2,000 g was compared with that of a similar group of infants whose mothers received antenatal glucocorticoids. A PDA was diagnosed on the basis of a typical heart murmur, increased precordial activity, and bounding peripheral pulses beyond the third day of life. Whereas 14 (44%) of 32 infants who were not exposed to antenatal glucocorticoids showed evidence of a PDA, only one (6.5%) of 15 infants whose mothers received antenatal glucocorticoids had similar findings. The incidence of ruptured membranes (>72 hours), the number of infants who were small for gestational age, and clinical management of the infants in the two groups were similar.

(Am J Dis Child 1983;137:336-338)