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May 1983

Sustained-Release Theophylline: Pharmacokinetic and Therapeutic Comparison of Two Preparations

Am J Dis Child. 1983;137(5):469-473. doi:10.1001/archpedi.1983.02140310051015

• The serum theophylline concentration profiles and clinical efficacy of two sustained-release theophylline tablets (Quibron-T/SR and Theo-Dur) were compared in 13 asthmatic children requiring continuous theophylline therapy. Quibron-T/SR and Theo-Dur, administered every 12 hours in the same dose for one week, were evaluated in a multiple-dose randomized crossover study. At the end of each week, serial serum theophylline concentrations were measured and spirometry and body plethysmography were performed. No significant differ