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May 1983

Sustained-Release Theophylline: Pharmacokinetic and Therapeutic Comparison of Two Preparations

Author Affiliations

From the Department of Pediatrics (Drs Menendez and McWilliams) and the School of Pharmacy (Dr Kelly and Ms Howick), University of New Mexico, Albuquerque.

Am J Dis Child. 1983;137(5):469-473. doi:10.1001/archpedi.1983.02140310051015

• The serum theophylline concentration profiles and clinical efficacy of two sustained-release theophylline tablets (Quibron-T/SR and Theo-Dur) were compared in 13 asthmatic children requiring continuous theophylline therapy. Quibron-T/SR and Theo-Dur, administered every 12 hours in the same dose for one week, were evaluated in a multiple-dose randomized crossover study. At the end of each week, serial serum theophylline concentrations were measured and spirometry and body plethysmography were performed. No significant differ