• Ninety-four well-nourished, bottle-fed infants with hypernatremic (N = 61) or hyponatremic (N=33) diarrheal dehydration were treated with oral rehydration. In 61 hypernatremic and 25 hyponatremic infants, two thirds of the fluid volume were given as glucose/electrolyte solution containing 90 mmole of sodium per liter and one third as plain water; the other eight hyponatremic infants were given glucose/electrolyte solution alone. Fluid deficits were successfully and rapidly replaced with oral therapy alone in all 61 hypernatremic infants (mean±SEM, 8.5±0.6 hours) and in 31 of those with hyponatremia (mean ± SEM, 10 ±1.2 hours). Two hypernatremic infants required some intravenous (IV) fluids. The mean serum sodium levels fell in the hypernatremic infants to normal and rose in those with hyponatremia. Only five (8%) of the 61 hypernatremic infants manifested convulsions during oral rehydration; this compared favorably with the 14% rate of convulsions encountered previously when we used IV rehydration.
(Am J Dis Child 1983;137:730-734)
Pizarro D, Posada G, Villavicencio N, Mohs E, Levine MM. Oral Rehydration in Hypernatremic and Hyponatremic Diarrheal Dehydration: Treatment With Oral Glucose/Electrolyte Solution. Am J Dis Child. 1983;137(8):730–734. doi:10.1001/archpedi.1983.02140340014003
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