A female infant was born after a 38-week gestation and normal labor and delivery. An ultrasound examination of her mother's abdomen two months before delivery demonstrated fetal microcephaly, but the pregnancy was otherwise uneventful. The infant's head circumference (26 cm) was far below the tenth percentile as compared with her body length and weight, which were near the tenth percentile. She had generalized petechiae and hepatosplenomegaly. Funduscopic examination showed retinal perivascular hemorrhage and exudate. Roentgenographic (Figs 1 and 2) and computed tomographic (CT) (Fig 3) findings were obtained.
Denouement and Discussion
Intracranial Calcification With Cytomegalovirus
This infant's symptoms were suggestive of a congenital viral or parasitic infection because of the presence of microcephaly, petechiae, retinopathy, and hepatosplenomegaly. Congenital
Roach ES, Sumner TE, Volberg FM, Boyle RJ, Young LW. Radiological Case of the Month. Am J Dis Child. 1983;137(8):799–800. doi:https://doi.org/10.1001/archpedi.1983.02140340079020
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: