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September 1983

Malignant Diseases of Infancy, Childhood, and Adolescence

Author Affiliations

Department of Pediatrics Arizona Health Sciences Center 1501 N Campbell Ave Tucson, AZ 85724

Am J Dis Child. 1983;137(9):924. doi:10.1001/archpedi.1983.02140350096034

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As Altman and Schwartz note in their preface to the second edition, there has been a virtual explosion of new knowledge in pediatric oncology during the five years since the publication of the first edition of this text. The new edition has been appropriately revised to reflect these advances. The chapter on cancer chemotherapy has been expanded to include sections on the use of indwelling catheters for the administration of chemotherapy and the treatment of emesis as a complication of cancer chemotherapy. The chapter on radiation therapy has been rewritten and is more completely referenced. More recent oncologic advances are described, including the application of monoclonal antibodies, the identification of nonrandom chromosomal abnormalities in leukemia, and the development of immunologic characterization of lymphoproliferative disorders. The text also includes a detailed discussion of the benefits and complications of CNS sanctuary therapy in leukemia. New chapters have been added that cover the