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Article
October 1983

Desmopressin Response of Enuretic Children: Effects of Age and Frequency of Enuresis

Author Affiliations

From the Department of Pediatrics, SUNY Upstate Medical Center, Syracuse, NY (Drs Post and Richman), the Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City (Drs Blackett and Duncan), the Department of Pediatrics, University of Illinois Medical Center, Chicago (Dr Miller), and Lutheran General Hospital, Park Ridge, Ill (Dr Miller).

Am J Dis Child. 1983;137(10):962-963. doi:10.1001/archpedi.1983.02140360026009
Abstract

• To characterize the children with enuresis likely to respond to desmopressin acetate, we performed a double-blind crossover study that included the use of a placebo. During the two weeks of desmopressin administration, six children (12%) had 13 or 14 dry nights, and 15 children (29%) had eight to 12 dry nights. Among the 17 children aged 9 years or older, with four to seven dry nights during the two-week baseline period, 12 children (71%) responded to desmopressin (eight to 14 dry nights). In contrast, none of the 15 children younger than 9 years of age with fewer than three dry nights before therapy responded. During the posttreatment period, only four of the 21 drug responders reported a persistent effect. Desmopressin may be effective in reducing the frequency of enuresis, especially in children older than 9 years of age without nightly enuresis.

(Am J Dis Child 1983;137:962-963)

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