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November 1983

Nail Dysplasia and Fetal Alcohol Syndrome: Case Report of a Heteropaternal Sibship

Author Affiliations

From the Department of Pediatrics, University of California, San Francisco (Dr Crain); the Genetic Disease Section, California Department of Health Services, Maternal and Child Health Branch, Berkeley, Calif (Ms Fitzmaurice); and the Department of Pediatrics, Kaiser-Permanente Medical Center, Walnut Creek, Calif (Dr Mondry).

Am J Dis Child. 1983;137(11):1069-1072. doi:10.1001/archpedi.1983.02140370031011

• We found substantial dysplasia of fingernails and toenails in each of four siblings demonstrating other features consistent with a diagnosis of fetal alcohol syndrome (FAS). This aspect of examination Is frequently overlooked in routine physical assessments. All four affected teenagers of this heteropaternal sibship demonstrated common features of FAS, including moderate mental retardation, maxillary hypoplasia, an elongated philtrum, and narrow palpebral fissures, as well as absence or dysplasia of two or more nails. Although nail hypoplasia has been previously reported as a minor finding in FAS, a literature review confirmed that nail dysplasia is found in more than 20% of individuals with FAS.

(Am J Dis Child 1983;137:1069-1072)