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December 1983

Disseminated Parainfluenza Infection in a Child With Severe Combined Immunodeficiency

Author Affiliations

From the Departments of Pediatrics (Drs Frank, Warren, and Wilfert and Ms Zeller) and Pathology (Dr Tucker), Duke University Medical Center, Durham, NC. Dr Frank is now with the Sterling-Winthrop Research Institute, Rensselaer, NY.

Am J Dis Child. 1983;137(12):1172-1174. doi:10.1001/archpedi.1983.02140380032010

• An 8-month-old male infant with severe combined immunodeficiency syndrome was admitted to the hospital with pneumonitis and, subsequently, died at 21 months of age. During his lengthy hospitalization, parainfluenza virus type 3 (PIV-3) was isolated from respiratory secretions and unusual sites, such as pericardial fluid, CSF, and WBCs. A postmortem examination showed apparent viral pancreatitis, and PIV-3 was isolated from the lung, brain, and pericardial fluid. To our knowledge, this is the first reported case of disseminated parainfluenza infection identified during life. We speculated that a mutant fusion protein may have been elaborated by the virus, allowing dissemination beyond the respiratory tract.

(Am J Dis Child 1983;137:1172-1174)