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May 1984

Hemophilus influenzae Type b Meningitis in Infant Rabbits: Pathogenesis and Therapy

Author Affiliations

From the Division of Infectious Diseases, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City.

Am J Dis Child. 1984;138(5):455-458. doi:10.1001/archpedi.1984.02140430033009

• A model of human Hemophilus influenzae type b meningitis was developed in infant rabbits infected intranasally. The pathogenesis and course resembled that in human beings; bacteremia was followed by meningitis with a high mortality. Pretreatment of the nasopharyngeal mucosa with 0.5% trypsin or normal saline significantly increased the rate of bacteremia. Death was age related. Intranasal challenge with type f and nontypeable H influenzae was associated with transient bacteremia. Our results suggest that factors on the respiratory tract epithelial cell surface influence colonization and infection with H influenzae type b and confirm the importance of other host and parasite factors. Intravenous aztreonam resulted in a peak CSF concentration that was 6% to 7% of the serum concentration in infected meninges but only 2% to 3% in normal meninges. Aztreonam reduced mortality in established H influenzae type b meningitis from 88% in untreated animals to 9%.

(AJDC 1984;138:455-458)

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