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July 1984

Necrotizing Enterocolitis and Hemolysis Associated With Clostridium perfringens

Am J Dis Child. 1984;138(7):686-688. doi:10.1001/archpedi.1984.02140450068021

• Two newborns had necrotizing enterocolitis (NEC) and severe hemolytic anemia. Clostridium perfringens was identified in the peritoneal fluid of both infants, supporting the previous association of C perfringens with hemolysis reported in adult patients. Infants with NEC and hemolytic anemia should be aggressively treated with surgical debridement and high-dose parenteral penicillin G potassium. Similarly, Gram's stain of peritoneal fluid and resected bowel at laparotomy for NEC may be useful for early identification of the primary organism.

(AJDC 1984;138:686-688)