• We evaluated the efficacy and side effects of a low dose of oral clonidine hydrochloride on growth hormone release in 24 healthy short children; ten received 100 μg (group A) and 14 received 50 μg (group B). The mean±SD growth hormone peak at 60 minutes was 14.5± 6.3 mg/mL in group A v11.6±6.1 mg/mL in group B. Failure rate (growth hormone<10 mg/mL) was 10% in group A and 36% in group B. The drop in cortisol levels was similar in both groups. Blood pressure did not change significantly, and only mild somnolence was noted in all. A single dose of oral clonidine hydrochloride approximating 100 μg/sq m, followed by one blood sample after 60 minutes seems to be an effective and safe screening test for growth hormone deficiency in short children.
Roberto Lanes, Bridget Recker, Pavel Fort, Fima Lifshitz. Low-Dose Oral ClonidineA Simple and Reliable Growth Hormone Screening Test for Children. Am J Dis Child. 1985;139(1):87–88. doi:10.1001/archpedi.1985.02140030093040