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April 1985

Chronic T-Cell Lymphocytosis With Neutropenia: Its Association With Epstein-Barr Virus Infection

Author Affiliations

From the Department of Pediatrics, University of Tennessee Center for the Health Sciences, Memphis (Dr Herrod); the Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis (Dr Wang); and the Department of Pediatrics, University of Massachusetts, Worcester (Dr Sullivan).

Am J Dis Child. 1985;139(4):405-407. doi:10.1001/archpedi.1985.02140060087037

• Chronic T-cell lymphocytosis with neutropenia has primarily been reported in adults. We have cared for a 14-year-old patient with this condition for over five years. This patient consistently had greater than 90% lymphocytes in his differential cell count. The majority of these cells had the OKT8 phenotype. Serologic studies demonstrated evidence for a chronic Epstein-Barr infection with elevated antibody titers to both early antigen and to the viral capsid antigen. Patients presenting with this condition should be carefully evaluated for possible viral infection.

(AJDC 1985;139:405-407)