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June 1985

Alternate Causes of Pseudotumor Cerebri-Reply

Author Affiliations

University of Nebraska Medical Center 42nd and Dewey Avenue Omaha, NE 68105

Am J Dis Child. 1985;139(6):545-546. doi:10.1001/archpedi.1985.02140080015014

In Reply.—Dr Van Dop's contention that a decrease in the serum cortisol concentration may have been an "alternate cause for the pseudotumor cere

bri" of patient 1 appears unlikely. During liotrix treatment, the morning cortisol values of patient 1 were 2.8, 2.9, and 5.3 μg/dL (normal, 7 to 20 μg/dL), respectively, between 8 and 9 AM on three consecutive days. The morning corticotropin value was 26 pg/mL (normal, <120 pg/mL), the serum cortisol value was 2.2 μg/dL, and the cortisol response to insulin-induced hypoglycemia was only 10 μg/dL. The liotrix treatment was discontinued for four weeks prior to cortisone replacement, yet the serum cortisol value remained abnormally low (3.2 μg/dL), along with the serum thyroxine value (3.6 μg/dL [normal, 4.5 to 12 μg/dL]) and the thyrotropin value (5.2 μU/mL). Cortisone acetate replacement was then begun. Clinical evidence of pseudotumor cerebri continued during this period.

The authors acknowledge the association