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July 1985

Treatment of Respiratory Failure Associated With Acute BRONCHIOLITIS

Author Affiliations

Bronx Municipal Hospital Center Department of Pediatrics Pelham Parkway South and Eastchester Road Bronx, NY 10461

Am J Dis Child. 1985;139(7):650-651. doi:10.1001/archpedi.1985.02140090012006

Sir.—The report of Outwater and Crone1 was interesting to me since it suggests that theophylline may be useful in the treatment of respiratory failure associated with acute viral bronchiolitis. In 19822 I reported my results using intravenous (IV) aminophylline to treat nine infants with acute bronchiolitis, aged 5 to 20 weeks, in respiratory failure. My method was very similar to that described by Outwater and Crone, 5 to 9 mg/kg of aminophylline IV over 20 minutes, followed by 0.5 to 1.0 mg/kg/hr until the patient was stabilized.

All infants had been admitted to the Pediatric Intensive Care Unit of the Bronx (NY) Municipal Hospital Center; they had tachypnea, wheezing, radiographic hyperaeration, and an arterial carbon dioxide pressure of 45 mm Hg or greater. One to two hours after IV aminophylline the arterial carbon dioxide pressure decreased from an average of 53 to 42 mm Hg (P<.001);