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July 1985

Isoenzyme Studies in Transient Hyperphosphatasemia of Infancy: Ten New Cases and a Review of the Literature

Author Affiliations

From the Division of Pediatrics, Section of Gastroenterology, Lutheran General Hospital, Park Ridge, Ill (Drs Kraut and Metrick); and the Division of Medicine, Section of Gastroenterology, New England Medical Center, Boston (Ms Maxwell and Dr Kaplan).

Am J Dis Child. 1985;139(7):736-740. doi:10.1001/archpedi.1985.02140090098042

• A literature review and ten new cases of benign transient hyperphosphatasemia of infancy are presented, with special attention paid to isoenzyme studies. Polyacrylamide gel electrophoresis, heat denaturation, and binding of alkaline phosphatase to anti–human alkaline phosphatases showed that the sources of the elevated alkaline phosphatase levels are normal bone and liver and not the small intestine. The data also suggest that the following criteria be present for a diagnosis of transient hyperphosphatasemia: (1) an age of less than 5 years, (2) variable symptoms, (3) no bone or liver disease noted on physical examination or (4) from laboratory investigations, (5) isoenzyme analysis showing elevations in both bone and liver activity, and (6) a return to normal serum alkaline phosphatase activity values within four months.

(AJDC 1985;139:736-740)