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September 1985

Measles Reimmunization

Author Affiliations

Hastings Foundation Infectious Disease Research Laboratory
Department of Pediatrics University of Southern California School of Medicine Los Angeles, CA 90033

Am J Dis Child. 1985;139(9):857-858. doi:10.1001/archpedi.1985.02140110011003

Sir.—We read with interest the article by Lampe et al1 concerning measles reimmunization in children immunized before 1 year of age. The data were compared with our earlier publication.2 It is important to recognize that Lampe et al have included 13 of the 18 infants who responded to the first dose of measles vaccine. Our study included 37 infants who were selected because each had failed to develop detectable hemagglutination inhibition (HI) antibody at a dilution ≥1:8 by four or more weeks after inoculation and had undetectable titer at the time of inoculation. For a true comparison, only five of the infants in their study qualify. Because each of these five infants developed detectable HI antibody, the authors did not identify any nonresponders to the second dose. However, it should be appreciated that, as in the present report, 24 of our 37 infants had HI antibody detectable