[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
September 1985

Juvenile Metabolic Gout

Author Affiliations

Department of Pediatrics College of Physicians and Surgeons of Columbia University Babies Hospital 3959 Broadway New York, NY 10032

Am J Dis Child. 1985;139(9):860-861. doi:10.1001/archpedi.1985.02140110014011

Sir.—In their report Yarom et al1 comment on the association of secondary gout in childhood with inborn errors of purine metabolism, glycogen storage disease type I, familial syndromes of hyperuricemia and renal disease, severe uremia, and myeloproliferative disorders (leukemia and lymphoma), but they make no mention of secondary juvenile metabolic gout caused by well-compensated intracorpuscular hemolysis.2 Although Vora3 has eloquently described juvenile gout associated with well-compensated hemolysis without anemia due to deficiency of isozymes of phosphofructokinase, and though we have emphasized the importance of measuring red blood cell phosphofructokinase and its isozymes in children with unexplained gout,4 we find no mention of this subject or these studies by Yarom et al.1 We also find no mention of reticulocyte count or red blood cell survival time. We note the hemoglobin value of 16.9 mg/dL in their 14-year-old female patient (case 2) and wonder whether her