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October 1985

Spontaneous Resolution of Cryptosporidiosis in a Child With Acquired Immunodeficiency Syndrome

Author Affiliations

Pediatric Clinic and Group Practice
Ambulatory Pediatrics Harbor/UCLA Medical Center 1000 W Carson St, Bin 437 Torrance, CA 90509

Am J Dis Child. 1985;139(10):967. doi:10.1001/archpedi.1985.02140120013016

Sir.—We report a child with acquired immunodeficiency syndrome (AIDS) who developed cryptosporidiosis that resolved before antimicrobial therapy was initiated.

Patient Report.—The patient, a male infant, was the 1,350-g product of a 31-week gestation born to a nondrug-addicted mother (gravida 13/para 6/abortus 7). The neonatal period was complicated and the infant underwent two double-volume exchange transfusions, three packed red blood cell transfusions, and one platelet transfusion.

At 8 months of age, he manifested failure to thrive, oral and cutaneous candidiasis unresponsive to nystatin, salmonellal gastroenteritis, recurrent otitis media, generalized lymphadenopathy, and hepatosplenomegaly. He was managed with prophylactic administration of trimethoprim-sulfamethoxazole and high-caloric-formula supplement. He has been followed up for two years. Candidiasis, lymphadenopathy, and hepatosplenomegaly have resolved, and he has had two isolated episodes of otitis media.

Significant laboratory tests at 33 months of age included: IgG, 3,300 mg/dL; IgM, 250 mg/dL; IgA, 64 mg/dL; IgD, not detected; cutaneous