Sir.—We read with great interest the article by Lanes et al.1 As the group who suggested to use clonidine as a test for growth hormone secretion in 1979,2 we are very pleased that other groups have found this test useful and simple. Dr Lanes and colleagues propose a standard dose of 50 μg. We have tested a single dose of 25 μg3 and found it sufficient for an initial screening test. If negative (the range of false-negatives being from 20-35), the test should be repeated using a higher dose, preferably 75 μg/sq m, 4 with the dose-response effect of clonidine on growth hormone secretion being linear.3
LARON Z, GIL-AD I. Low-Dose Oral Clonidine. Am J Dis Child. 1985;139(11):1073. doi:10.1001/archpedi.1985.02140130011007
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