Sir.—We were interested to read the article in the April issue of AJDC by Laungani and colleagues1 about the
Summary of Cerebrospinal Fluid (CSF) β-Endorphinlike Immunoreactivity Found in the First Three Days of Life CSF β-Endorphin, pg/mL Mean Range SEM First 3 days, asphyxia 22 109 39-184 8.7 First 3 days, no asphyxia 10 34 24-45 2.3 <.001 First 24 hr, asphyxia 13 122 75-184 9.4 First 24 hr, no asphyxia 6 31 25-39 2.4 <.001 correlation between Apgar scores and cerebrospinal fluid (CSF) β-endorphinlike immunoreactivity. Their results are very similar to the observations of my colleagues and I in a comparable group of neonates.2 We, however, found no correlation between one-minute Apgar scores and β-endorphinlike immunoreactivity from CSF taken in the first 24 hours or three days of life, as found by Dr Laungani. We did, however, find a statistically significant difference between those neonates who