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Article
July 1986

Human T-Cell Lymphotropic Virus Type III (HTLV-III) Embryopathy: A New Dysmorphic Syndrome Associated With Intrauterine HTLV-III Infection

Author Affiliations

From the Divisions of Immunology (Drs Wiznia and Rubinstein) and Genetics (Drs Marion and Hutcheon) of the Department of Pediatrics, and the Departments of Pediatrics and Microbiology & Immunology (Dr Rubinstein), Albert Einstein College of Medicine, Bronx, NY.

Am J Dis Child. 1986;140(7):638-640. doi:10.1001/archpedi.1986.02140210036020
Abstract

• Twenty infants and children with positive serologic tests for the human T-cell lymphotropic virus type III (HTLV-III) were noted to have similar features including growth failure (75%), microcephaly (70%), and craniofacial abnormalities consisting of ocular hypertelorism (50%); prominent box-like appearance of the forehead (75%); flat nasal bridge (70%); mild upward or downward obliquity of the eyes (65%); long palpebral fissures with blue sclerae (60%); short nose with flattened columella and well-formed, triangular philtrum (65%); and patulous lips (60%). These features constitute a new and distinct dysmorphic syndrome, the HTLV-III embryopathy.

(AJDC 1986;140:638-640)

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