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September 1986

Late-Onset Tetany With Hypocalcemia and Hyperphosphatemia

Author Affiliations

Department of Pediatrics University of South Dakota School of Medicine 1100 S Euclid Ave Sioux Falls, SD 57117-5039

Am J Dis Child. 1986;140(9):854-855. doi:10.1001/archpedi.1986.02140230024012

Sir.—The article by Venkataraman et al1 described late infantile tetany and secondary hyperparathyroidism presumably due to the high phosphorus load in humanized cow milk formula. The letter from Bancroft2 described an additional case of this type of late hypocalcemic tetany, and he wondered if other cases had been seen. I wish to report late-onset tetany with hypocalcemia and hyperphosphatemia in two sisters that was similar in course to that described by Venkataraman et al and Bancroft, but in which a significant factor was maternal hyperparathyroidism and hypercalcemia.

Patient Reports.—Patient 1.—A 2900-g female neonate, the product of an uncomplicated term pregnancy, labor, and delivery, was born to a gravida 3, para 3 mother. After an uneventful hospital course, she was discharged home on a regimen of a humanized cow milk formula (Similac, Ross Laboratories, Columbus, Ohio). When the neonate was 9 days old, the mother noted

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