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October 1986

Lorazepam in the Treatment of Refractory Neonatal Seizures: A Pilot Study

Author Affiliations

From the Division of Pediatrics (Dr Wittert), Sections of Pediatric Neurology (Dr Schnitzler) and Neonatology (Drs Deshmukh and Mangurten), Lutheran General Hospital, Park Ridge, Ill.

Am J Dis Child. 1986;140(10):1042-1044. doi:10.1001/archpedi.1986.02140240088032

• Seven neonatal patients with severe seizures unresponsive to conventional anticonvulsant therapy were treated with lorazepam. Immediate cessation of seizure activity occurred in all patients within five minutes. Although seizures recurred in two infants eight hours later, frequency and severity diminished. There were no apparent significant side effects attributed to the medication.

(AJDC 1986;140:1042-1044)