Sir.—Central nervous system disease secondary to vaccine poliovirus infection is a well-documented phenomenon both in immunocompromised children and in the normal host.1,2 Myocarditis and pneumonitis have not been previously reported as a consequence of vaccinelike strains, to our knowledge, and a diffuse encephalomyelitis is rare. We herein describe a 5-month-old infant who developed multiple organ dysfunction secondary to infection by vaccine poliovirus type 2 acquired by household exposure.
Report of a Case.—A 5-month-old male infant presented with failure to thrive and respiratory distress after receiving a regimen of nasal betamethasone dipropionate, 1 mg/d, for three months, which had been prescribed by a local physician for nasal congestion. Recurrent bilateral otitis media, oral thrush, and a monilial rash had become persistent problems. A temperature of 40.6°C accompanied by marked respiratory distress necessitated admission to our hospital. Significant history included the fact that two family members, both children, had
RASCH DK, WELLS O, FOWLKES J. Fatal Disseminated Infection due to Poliovirus Type 2 Vaccine. Am J Dis Child. 1986;140(12):1211–1212. doi:10.1001/archpedi.1986.02140260013004
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: