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March 1987

The Use of Theophylline Clearance in Pediatric Status Asthmaticus: I. Interpatient and Intrapatient Theophylline Clearance Variability

Author Affiliations

From the Division of Allergy-Immunology-Pulmonology and Bone Marrow Transplantation, Children's Hospital of Philadelphia, and the Department of Pediatrics, University of Pennsylvania, Philadelphia.

Am J Dis Child. 1987;141(3):282-287. doi:10.1001/archpedi.1987.04460030060025

• A group of 167 pediatric asthmatics were followed up over four years, and their theophylline clearance values were recorded when they were admitted for status asthmaticus. A slow and gradual decrease of the clearance value was noted in all age groups. The clearance did not change significantly between the ages of 2 and 9 years. Longitudinal intrapatient clearance changes achieved statistical significance after the age of 9 years. When the patient groups were studied according to their initial clearance values, it became evident that only the patients with clearance values of 80 mL/kg/h showed significant changes of this value. In our patient group, obesity did not play a significant role in effecting a change in theophylline clearance.

(AJDC 1987;141:282-287)

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