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June 1987

Sickle Cell AnemiaReport of Two Cases in Children, With Necropsy in One Case

Am J Dis Child. 1987;141(6):612-615. doi:10.1001/archpedi.1987.04460060030025

J. B. Herrick,1 in 1910, reported a peculiar dyscrasia characterized by severe anemia, with the occurrence in the blood of elongated and sickle-shaped erythrocytes. Three instances of this condition have since been described, one by R. E. Washburn;2 one by Cook and Myer,3 and one by V. R. Mason.4 Emmel5 further studied the blood of Cook and Myer's case, demonstrating the existence of phagocytosis of the erythrocytes by large mononuclear leukocytes in the peripheral circulation. He also pointed out the fact that when sealed sterile preparations of the fresh blood were allowed to stand at room temperature for varying periods of time, many of the circular erythrocytes underwent transformation into elongated and sickle shapes similar to those seen in the freshly drawn blood. Furthermore, he showed that the blood of the patient's father, though normal to all appearances when drawn, underwent similar changes on standing. Guthrie

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