• A child with the Alagille syndrome of intrahepatic bile duct paucity developed hepatocarcinoma. Disabling cirrhosis had rendered this child a suitable candidate for transplantation before the discovery of carcinoma. However, the extension of the tumor outside the liver precluded the performance of this potentially life-saving operation. Serial monitoring of the serum μ-fetoprotein concentration may be of value in the early identification of tumors in pediatric candidates for transplantation.
Kaufman SS, Wood RP, Shaw BW, Markin RS, Gridelli B, Vanderhoof JA. Hepatocarcinoma in a Child With the Alagille Syndrome. Am J Dis Child. 1987;141(6):698–700. doi:10.1001/archpedi.1987.04460060114050
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