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September 1987

Lack of Effect of Lithium Carbonate in Patients With Glycogenosis Ib

Author Affiliations

From the Sections of Hematology/Oncology (Dr Mahoney) and Infectious Disease (Dr Anderson) Department of Pediatrics, Baylor College of Medicine, Houston; Sections of Hematology/Oncology (Dr Ambruso) and Genetics (Dr McCabe), Department of Pediatrics, University of Colorado School of Medicine, Denver; and Institute of Child Health, London (Drs Leonard and Dunger).

Am J Dis Child. 1987;141(9):985-986. doi:10.1001/archpedi.1987.04460090062025

• Lithium carbonate has been observed to induce neutrophilia in psychiatric patients and has been used in a number of childhood neutropenic disorders. We tried lithium carbonate in three children with glycogenosis Ib to see if the drug would alleviate the neutropenic complications of the disorder. Mean absolute neutrophil counts rose in one patient but not in the other two. Despite high-dosage schedules, serum lithium levels were highly erratic. Two patients developed potentially severe side effects, including polyuria, diarrhea, and altered mental status. One patient developed pneumonia despite a neutrophil count rise in response to therapy. Lithium carbonate is not useful in patients with glycogenosis Ib.

(AJDC 1987;141:985-986)