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October 1987

Hemostasis Defects and Periventricular-Intraventricular Hemorrhage-Reply

Author Affiliations

Neonatal Unit, Department of Pediatrics
Hemostasis and Thrombosis Research Unit University Hospital Leiden Bldg 10, Rijnsburgerweg 10 2333 AA Leiden the Netherlands

Am J Dis Child. 1987;141(10):1041. doi:10.1001/archpedi.1987.04460100018011

In Reply.—In our first report we stated that infants who developed PIVH during the study period required more plasma transfusions during the first week of life but that plasma transfusion itself appeared to be no antecedent of PIVH.1 In our second report2 we mentioned explicitly that the clotting factor levels on day 1 in infants, who died during the study period were not different from those of the other infants enrolled in the study.

To allow comparison among all infants we decided only to study the infants who survived the whole study period. Beverley and coworkers3 found no statistical differences among the infants with PIVH and without PIVH in any of the clotting factors at birth, although after subdivision of infants with PIVH according to the severity of the hemorrhage, the infants with more severe hemorrhages had evidence of coagulopathy at birth. Beverley et al also

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