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November 1987

Early Detection of Congenital Cardiovascular Malformations in Infancy

Author Affiliations

From the Department of Epidemiology and Preventive Medicine (Drs Rubin and Ferencz) and the Division of Pediatric Cardiology (Dr Brenner), University of Maryland School of Medicine, and the Department of Pediatrics, The Johns Hopkins University (Dr Neill), Baltimore; and the Department of Cardiology, Children's Hospital National Medical Center, Washington, DC (Dr Perry).

Am J Dis Child. 1987;141(11):1218-1220. doi:10.1001/archpedi.1987.04460110088031

• In an ongoing population-based study of congenital cardiovascular malformations in the Baltimore–Washington, DC, area, 1527 affected infants were ascertained from multiple sources during the years 1981 to 1984. Ninety-eight percent were evaluated at a regional pediatric cardiology center. Among the unreferred cases, in which the cardiac defect was diagnosed only at autopsy, most infants died in the first week of life and had associated problems, such as low birth weight, major noncardiac malformations, or other life-threatening illnesses, but a few Infants with potentially remediable heart disease escaped clinical detection. Until preventive measures become available, reduction of infant mortality due to congenital cardiovascular malformations will continue to depend on early recognition of signs of serious heart disease in infants and on effective community-wide use of specialized cardiac services.

(AJDC 1987;141:1218-1220)