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November 1987

Antidiuretic Hormone Excess in Infant Botulism

Author Affiliations

From the Departments of Pediatrics, University of California, Davis, School of Medicine (Dr Kurland), and University of California, San Diego (Dr Seltzer).

Am J Dis Child. 1987;141(11):1227-1229. doi:10.1001/archpedi.1987.04460110097033

• Two infants developed evidence of antidiuretic hormone excess as a complication of infant botulism. Neither child received mechanical ventilatory support before the development of hyponatremia, serum hyposmolality, and urinary hyperosmolality. Both infants responded to fluid-intake restriction. The appearance of hyponatremla in an infant with botulism should suggest antidiuretic hormone excess. The recognition of this entity will lead to Its appropriate management with fluid-intake restriction.

(AJDC 1987;141:1227-1229)