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December 1987

Premature Thelarche in Puerto Ric[ill]

Author Affiliations

Department of Community and Occupational Health Meharry Medical College 1005 D. B. Todd Blvd Nashville, TN 37208

Am J Dis Child. 1987;141(12):1250-1251. doi:10.1001/archpedi.1987.04460120012006

Sir.—I read with interest the article about premature thelarche in Puerto[ill] Rico in the December 1986 issue o[ill] AJDC.1 The authors found positive statistical associations between premature thelarche and consumption of various meat products and soy-based formula, and a maternal history of ovarian cysts. Although the retrospec[ill] tive nature of the study leads to the possibility of measurement bias due to inaccurate recall, the authors should be commended for the methods they used to minimize this bias via a stan[ill] dardized two-part interview administered by two different interviewers The selection process utilized for obtaining case subjects and controls (matched pairs) add strength to ththe selection process. Other strengths of the study include the multivariate logistic regression analysis to compute[ill] odds ratio, with exact confidence intervals to determine significant statistical associations.

I agree with the authors' comments that the association found with consumption of fresh chicken may be due

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