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February 1988

Neuron-Specific Enolase in Comatose Children

Author Affiliations

From the Division of Neurology (Drs Nara, Nozaki, and Nakae) and the Department of Radiology (Mr Arai), Saitama (Japan) Children's Medical Center; and the Department of Pediatrics (Dr Ohashi), Jikei University School of Medicine, Tokyo.

Am J Dis Child. 1988;142(2):173-174. doi:10.1001/archpedi.1988.02150020075032

• Sequential examination of neuronspecific enolase in cerebrospinal fluid and serum was performed in 20 comatose children with acute encephalitis, acute encephalopathy, or Reye's syndrome. Neuron-specific enolase activities corresponded to the degree of brain damage. As neuron-specific enolase levels increased to greater than 80 ng/mL, patients had more severe impairment or died. Neuron-specific enolase may be a useful marker for evaluating the degree of neuronal damage and prognosis.

(AJDC 1988;142:173-174)

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