[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
August 1988

Hepatitis in Acquired Rubella Infection in Children

Author Affiliations

Department of Pediatrics Nippon Kokan Hospital 1-2-1 Kokandori Kawasaki-ku Kawasaki, Kanagawa, Japan
Department of Pediatrics Keio University School of Medicine, Tokyo Japan

Am J Dis Child. 1988;142(8):817-818. doi:10.1001/archpedi.1988.02150080023012

Sir.—Although congenital rubella frequently is accompanied by hepatocellular disease,1 liver involvement in acute acquired rubella, to our knowledge, has not been recognized.2,3 Recently, Zeldis et al4 reported a case of rubella accompanied by serum aminotransferase level elevations in an adult. We determined liver-derived serum enzyme levels in pediatric patients with rubella to clarify the incidence and clinical features of liver involvement.

Early in 1987, a rubella epidemic occurred in Japan. In this study, we analyzed 241 patients who were serologically confirmed to have rubella by a hemagglutination inhibition test.

At the first visit, we measured serum bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and its isoenzymes, alkaline phosphatase (AP), and γ-glutamyltransferase (GGT) levels. We arbitrarily defined liver dysfunction as an elevation of ALT level over 100 U/L. Normal reference interval levels are AST, 20 to 50 U/L; ALT, 10 to 40 U/L; and LDH,