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November 1988

Parent-Child Minimal Change Nephrotic Syndrome

Am J Dis Child. 1988;142(11):1140. doi:10.1001/archpedi.1988.02150110018008

Sir.—The two articles on IgA nephropathy that appeared in AJDC expanded our knowledge of this disease.1,2 After reading these articles, we would like to expand the spectrum of another common pediatric renal disease, minimal change nephrotic syndrome. While familial forms of minimal change nephrotic syndrome are not uncommon, the parent-child occurrence of this disease is essentially nonexistent.

Familial forms of minimial change nephrotic syndrome occur almost exclusively among siblings, with an incidence of approximately 3.3%.3,4 However, in our review of the English-language literature over the last 25 years, we found only one case of a parent-child occurrence of minimal change nephrotic syndrome.3 In this instance the father had onset of nephrotic syndrome at age 7 years and responded to corticotropin therapy but later had a relapse. The daughter had biopsy-proved minimal change nephrotic syndrome at 2 years of age that was responsive to prednisone therapy. We