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November 1988

Propranolol Treatment for Childhood Posttraumatic Stress Disorder, Acute TypeA Pilot Study

Author Affiliations

From the Department of Psychiatry, Harvard Medical School (Dr Famularo); the Department of Psychiatry, The Children's Hospital (Drs Famularo and Kinscherff); Boston Juvenile Court (Drs Famularo and Kinscherff); and the Department of Biostatistics, School of Public Health, Harvard University (Dr Fenton), Boston.

Am J Dis Child. 1988;142(11):1244-1247. doi:10.1001/archpedi.1988.02150110122036

• We report 11 cases of posttraumatic stress disorder. Each child had been physically abused or sexually abused or both and presented in an agitated, hyperaroused state. Using a B-A-B (off-on-off) medication design in a clinical setting, the children were treated with the beta-adrenergic antagonist propranolol. Scores on an inventory of symptoms of posttraumatic stress disorder indicated that patients exhibited significantly fewer symptoms while receiving medication than either before or after they received medication.

(AJDC 1988;142:1244-1247)