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December 1988

Nonsteroidal Anti-inflammatory Drugs in Pediatric Patients

Am J Dis Child. 1988;142(12):1281-1282. doi:10.1001/archpedi.1988.02150120035032

In this issue of AJDC, Olson et al1 offer preliminary evidence for the value of nonsteroidal anti-inflammatory drugs (NSAIDs) as an adjunct in the treatment of chronic iridocylitis in childhood. This is a vexingly difficult therapeutic problem, usually occurring in patients with juvenile rheumatoid arthritis (JRA). The only systemic agents heretofore effective are corticosteroid or immunosuppressive drugs. Although the study of Olson et al is a retrospective review of 14 patients, two types of evidence are offered to suggest a therapeutic benefit: (1) a decreased need for systemic or topical steroids and (2) reduction of inflammatory cells in the anterior chamber of the eye as estimated by slit-lamp examination. It was the impression of the authors that all 14 patients improved after NSAIDs were added to the regimen (I have a similar impression in two patients with uveitis in our own clinic). They point out that their patients had