[Skip to Navigation]
December 1988

IgM-Enriched Intravenous Immunoglobulin Therapy in Neonatal Sepsis

Author Affiliations

From the Department of Paediatrics, Division of Neonatology (Professor Haque) and College of Medicine Research Centre (Dr Bahakim), College of Medicine; and the Maternity and Children's Hospital (Dr Zaidi), Riyadh, Saudi Arabia.

Am J Dis Child. 1988;142(12):1293-1296. doi:10.1001/archpedi.1988.02150120047038

• Despite the development of newer generation of antibiotics, mortality from neonatal sepsis remains high. In a prospective, randomized study, we investigated the use of IgM-enriched immunoglobulin therapy in neonatal sepsis. Two groups of 30 infants each (matched for gestational age, sex, weight, and other variables) were randomly allocated to receive either antibiotics alone (control group) or antibiotics plus 5 mL/kg/d for four days of IgM-enriched immunoglobulin intravenously (immunotherapy group). Mortality from sepsis in the control group was 20% (6/30), while in the immunotherapy group it was 3.3%(1/30). We conclude that IgM-enriched immunoglobulin therapy in conjunction with antibiotic therapy significantly reduces mortality from neonatal sepsis.

(AJDC 1988;142:1293-1296)

Add or change institution