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December 1988

Danazol for Children With Immune Thrombocytopenic Purpura

Author Affiliations

From the Department of Pediatrics, Cornell University Medical College, New York, and the Department of Pediatric Hematology, North Shore University Hospital, Manhasset, NY (Drs Weinblatt and Kochen); and the Department of Pediatric Hematology, University of Southern California and Childrens Hospital of Los Angeles (Dr Ortega).

Am J Dis Child. 1988;142(12):1317-1319. doi:10.1001/archpedi.1988.02150120071043

• Ten patients with steroid-dependent or refractory immune thrombocytopenic purpura were treated with danazol in an attempt to improve their platelet counts. Nine of the ten children exhibited an excellent initial response to the drug, with five achieving a complete, unmaintained remission. Two others were able to have their prednisone doses tapered with a resultant disappearance of steroid-induced adverse effects. No significant adverse effects of danazol were noted. Danazol seems to be effective in the treatment of children with immune thrombocytopenic purpura and would warrant additional studies to determine its proper role in the management of this common pediatric ailment.

(AJDC 1988;142:1317-1319)